Yeh look there’s plenty of evidence that artificial sweeteners act differently in the body to sugar, and I’ve heard the receptor hypothesis before. The main thing for me is that blinded RCTs comparing people given sugar with people given artificial sweeteners show a modest decrease in weight from the sweeteners. It may be that sweeteners cause issues, but if you’re using them to replace sugar I think the benefits outweigh the problems.

Epidemiologist. Writer. Podcaster. Twitter https://twitter.com/GidMK FB www.facebook.com/gidmkhealthnerd/ Email gidmk.healthnerd@gmail.com