Of course ‘significant’ is subjective. However, I have rarely found someone willing to argue that 3,000 deaths per year is an insignificant number — the economic cost alone is enormous, and the societal cost is massive.
Your argument — 50%+ or nothing — seems to be a sidestep from your actual issue, the one of “rights”. It seems slightly strange, because I am certainly not arguing for repealing the 2nd. I guess it comes down to whether you consider requiring minimal administrative burdens for gun owners to be more problematic than the current enormous toll of gun deaths the US experiences each year.